PROMETHAZINE HCL PLAIN ORAL SOLUTION

Description

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PROMETHAZINE HCL PLAIN ORAL SOLUTION – promethazine hcl solution
ANI Pharmaceuticals, Inc.
Barcode = 7489
Promethazine HCl Plain Oral Solution
Rx Only
Rx Only
DESCRIPTION
Each teaspoon (5 mL) of Promethazine HCl Plain Oral Solution contains 6.25 mg promethazine HCl in a flavored syrup base with a

pH between 4.7 and 5.2. Alcohol 7%. The inactive ingredients present are artificial and natural flavors, citric acid, D&C Red 33, D&C

Yellow 10, FD&C Blue 1, FD&C Yellow 6, glycerin, saccharin sodium, sodium benzoate, sodium citrate, sodium propionate, water,

and other ingredients.

Promethazine HCl is a racemic compound; the empirical formula is C17H20N2S•HCl and its molecular weight is 320.88.

Promethazine HCl, a phenothiazine derivative, is designated chemically as 10H-Phenothiazine-10-ethanamine, N,N, α-trimethyl-,

monohydrochloride, (±)- with the following structural formula: plain jane promethazine syrup

Promethazine HCl occurs as a white to faint yellow, practically odorless, crystalline powder which slowly oxidizes and turns blue on
prolonged exposure to air. It is freely soluble in water and soluble in alcohol.
CLINICAL PHARMACOLOGY
Promethazine is a phenothiazine derivative which differs structurally from the antipsychotic phenothiazines by the presence of a
branched side chain and no ring substitution. It is thought that this configuration is responsible for its relative lack (1/10 that of
chlorpromazine) of dopamine antagonist properties.
Promethazine is an H1 receptor blocking agent. In addition to its antihistaminic action, it provides clinically useful sedative and
antiemetic effects.
Promethazine is well absorbed from the gastrointestinal tract. Clinical effects are apparent within 20 minutes after oral administration
and generally last four to six hours, although they may persist as long as 12 hours. Promethazine is metabolized by the liver to a
variety of compounds; the sulfoxides of promethazine and N-demethylpromethazine are the predominant metabolites appearing in the
urine.
INDICATIONS AND USAGE
Promethazine HCl Plain Oral Solution is useful for:

Perennial and seasonal allergic rhinitis.

Vasomotor rhinitis.

Allergic conjunctivitis due to inhalant allergens and foods.

Mild, uncomplicated allergic skin manifestations of urticaria and angioedema.

Amelioration of allergic reactions to blood or plasma.

Dermographism. buy juul pods classic tobacco

Anaphylactic reactions, as adjunctive therapy to epinephrine and other standard measures, after the acute manifestations have been

controlled.

Preoperative, postoperative, or obstetric sedation.

Prevention and control of nausea and vomiting associated with certain types of anesthesia and surgery.

Therapy adjunctive to meperidine or other analgesics for control of post-operative pain.

Sedation in both children and adults, as well as relief of apprehension and production of light sleep from which the patient can be

easily aroused.

Active and prophylactic treatment of motion sickness.

Antiemetic therapy in postoperative patients.

CONTRAINDICATIONS
Promethazine HCl Plain Oral Solution is contraindicated for use in pediatric patients less than two years of age. buy plain jane promethazine online| plain jane promethazine for sale